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HomeMental HealthDoes Zoloft Trigger Weight Achieve? — Talkspace

Does Zoloft Trigger Weight Achieve? — Talkspace

Revealed on: 03 Apr 2023

Zoloft, often known as sertraline, is an antidepressant treatment used to deal with melancholy, anxiousness, and different psychological well being situations. Whereas this selective serotonin reuptake inhibitor (SSRI) might be an efficient therapy of melancholy and anxiousness signs for many individuals, like several drug, there are potential psychological and bodily Zoloft unwanted effects that may include antidepressant use. A standard facet impact is Zoloft weight achieve. 

Not everybody experiences sertraline weight achieve. A lot of the time, analysis reveals that physique weight achieve is modest or non permanent. That mentioned, it’s nonetheless vital to know the potential facet impact and focus on it along with your physician earlier than beginning therapy.

Does Zoloft Trigger Weight Achieve?

Are you able to achieve weight on Zoloft? Some research have proven that round 11% of people that take antidepressants expertise a weight achieve of no less than 5% in the course of the first yr. Nonetheless, your unwanted effects might happen at totally different occasions relying on how lengthy it takes for Zoloft to work in your physique. Some analysis additionally suggests that different varieties of antidepressants may need a better danger than Zoloft. 

“Zoloft can probably trigger weight achieve, but it surely’s not a crucial facet impact for everybody. It’s greatest to get readability out of your psychiatrist about which antidepressant is the most effective match for you. You may get on one other treatment if you end up gaining weight.”

Talkspace therapist Bisma Anwar, LMHC

What different SSRIs trigger weight achieve?

Physique weight achieve generally is a facet impact of antidepressant use past simply Zoloft. Different selective serotonin reuptake inhibitors (SSRIs) that may trigger weight achieve embody: 

  • Prozac
  • Paxil
  • Celexa
  • Lexapro 

Weight achieve seems to be extra possible when taking greater doses or for individuals taking the antidepressant drug for prolonged durations.  


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Why Does Zoloft Trigger Weight Achieve?

The precise cause why you may achieve weight on Zoloft isn’t totally understood, however a number of theories exist. 

Elevated serotonin ranges

One idea means that elevated serotonin ranges within the mind attributable to SSRI medicine can have an effect on metabolism and starvation alerts within the physique. This may result in modifications in urge for food and consuming habits in addition to cravings for unhealthy meals, leading to weight achieve over time. 

Power ranges

One other risk for Zoloft weight achieve is that sure varieties of melancholy medicines intrude with power stability. For some individuals, antidepressant therapy might trigger them to turn into much less lively and burn fewer energy than they normally would. 

Hormones and metabolism

Some analysis means that long-term use of SSRI medicine might alter appetite-regulating hormones like leptin and ghrelin. Extra analysis is required, although, because it’s unclear if this outcomes in weight achieve.  

Sedative impact

Lastly, one other issue that would contribute to potential weight achieve from taking Zoloft may be its sedative impact. Zoloft could make you are feeling drowsy or sleepy in the course of the day. It’s believable that this might scale back your exercise degree and improve your likelihood of gaining weight resulting from a scarcity of bodily train.

How Can I Keep away from Gaining Weight on Zoloft?

For those who’re involved about Zoloft weight achieve, there are steps you may take to assist reduce this danger.

Nutritious diet

Sustaining a nutritious diet is vital to avoiding sertraline weight achieve. Consuming balanced meals with loads of fruits, greens, lean proteins, and complete grains may help you keep full longer and hold your power ranges up. 

As well as, you need to keep away from processed meals excessive in sugar and saturated fat, as these can result in weight achieve. It’s additionally vital to look at portion sizes; overeating any meals sort may cause undesirable kilos.

Get transferring & be lively

Getting lively is one other nice technique to keep away from gaining weight on Zoloft. Train helps burn energy and enhance metabolism, which is crucial for sustaining a wholesome weight. You don’t have to affix an costly fitness center or purchase fancy tools; merely strolling across the block or doing gentle stretching at residence will typically do the trick.

Make sleep a precedence

Making sleep a precedence is crucial for psychological well being on the whole. Lack of sleep can result in elevated urge for food resulting from hormones being out of stability, making it tougher for individuals who take this antidepressant treatment to keep up their present weight and stop additional features from occurring sooner or later. Maintain a wholesome sleep routine and goal for 7-8 hours per night time. It’s also possible to take brief naps all through the day.

Discuss to your physician about switching treatment

Discuss along with your physician about switching your antidepressant therapy if crucial. 

“One of the simplest ways to keep away from weight achieve resulting from Zoloft is to work carefully along with your psychiatrist. If you end up gaining weight, let your physician know so that you might be switched to a different antidepressant.”

Talkspace therapist Bisma Anwar, LMHC

In case your melancholy analysis and therapy plan suggest treatment for melancholy, your physician might be able to suggest different SSRIs which can be much less prone to trigger weight achieve.

Discuss to Your Physician About Zoloft Facet Results

It’s crucial for anybody contemplating beginning an antidepressant like Zoloft to know the dangers related to its use. 

For those who’re apprehensive about Zoloft and weight achieve or different unwanted effects, share your issues along with your physician.

On-line psychiatry from Talkspace can present skilled steering as you navigate the potential unwanted effects of a prescribed treatment. For those who’re involved with weight achieve on Zoloft, discover your therapy choices with a psychiatrist. Take management of your well being right now by in search of the best psychiatrist-prescribed treatment for you.


  1. Arterburn D, Sofer T, Boudreau D, et al. Lengthy-term weight change after initiating second-generation antidepressants. Journal of Scientific Drugs. 2016;5(4):48. doi:10.3390/jcm5040048. Accessed December 16, 2022.
  2. Gafoor R, Sales space HP, Gulliford MC. Antidepressant utilization and incidence of weight achieve throughout 10 years’ follow-up: Inhabitants based mostly cohort research. BMJ. 2018. doi:10.1136/bmj.k1951. material/361/bmj.k1951. Accessed December 16, 2022.
  3. Ozsoy S, Besirli A, Abdulrezzak U, Basturk M. Serum ghrelin and leptin ranges in sufferers with melancholy and the consequences of therapy. Psychiatry Investigation. 2014;11(2):167. doi:10.4306/pi.2014.11.2.167. Accessed December 16, 2022.

Talkspace articles are written by skilled psychological health-wellness contributors; they’re grounded in scientific analysis and evidence-based practices. Articles are extensively reviewed by our crew of medical specialists (therapists and psychiatrists of varied specialties) to make sure content material is correct and on par with present business requirements.

Our purpose at Talkspace is to offer probably the most up-to-date, priceless, and goal info on psychological health-related subjects in an effort to assist readers make knowledgeable choices.

Articles comprise trusted third-party sources which can be both straight linked to within the textual content or listed on the backside to take readers on to the supply.

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