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HomeMental HealthExtra Information on the Reproductive Security of Lurasidone and Quetiapine

Extra Information on the Reproductive Security of Lurasidone and Quetiapine


The Nationwide Being pregnant Registry for Atypical Antipsychotics was created with the intention to consider the security of atypical antipsychotic medicines taken by ladies throughout being pregnant. Since its inception, now we have enrolled over 3000 ladies within the registry, and now we have been in a position to publish knowledge on the reproductive security of aripiprazole (Abilify), olanzapine (Zyprexa) and quetiapine (Seroquel). Now now we have some preliminary knowledge on using lurasidone (Latuda) throughout being pregnant.

The Nationwide Being pregnant Registry for Atypical Antipsychotics is a potential pharmacovigilance program by which pregnant ladies between the ages of 18 and 45 are enrolled and interviewed throughout being pregnant. Medical data are reviewed to verify the presence or absence of main malformations. 

 Of the two,293 ladies enrolled on the time of research, there have been 134 within the lurasidone publicity group, 264 within the quetiapine publicity group, and 886 controls. The danger of main malformations was 2.19% within the lurasidone group, 1.85% within the quetiapine group, and 1.77% within the controls. Odds ratios evaluating lurasidone and quetiapine with controls have been 1.24 (95% confidence interval [CI] = 0.36-4.32) and 1.04 (95% CI = 0.38-2.85), respectively. No particular patterns of malformations have been noticed in infants uncovered to the medicines. 

Reassuring Information However Extra Information on Lurasidone is Wanted

The newer atypical or second-generation antipsychotic brokers are used to deal with a spectrum of psychiatric problems, together with psychotic problems, bipolar dysfunction, main melancholy, PTSD and different nervousness problems. Our knowledge on the reproductive security of those newer atypical brokers is rising. 

This research supplies reassuring knowledge concerning the security of prenatal publicity to lurasidone and quetiapine in a pattern of well-characterized individuals adopted prospectively and is according to earlier research assessing infants uncovered to this class of medicines. Primarily based on the findings of this research, it seems that lurasidone and quetiapine don’t seem like main teratogens. No research to date have demonstrated a rise in threat of malformations in youngsters uncovered to atypical antipsychotics.

Whereas the preliminary knowledge from this research is reassuring, bigger numbers of individuals are wanted to supply extra full knowledge concerning the reproductive security of atypical antipsychotics as a category of medicines. These findings, taken along with different research, counsel that prenatal publicity to atypical antipsychotics doesn’t seem to considerably enhance the chance for congenital malformations, though now we have only a few documented exposures to a number of the latest atypicals, together with lurasidone (Latuda), iloperidone (Fanapt), brexpiprazole (Rexulti), and cariprazine (Vraylar).

The Nationwide Being pregnant Registry for Atypical Antipsychotics continues to recruit pregnant ladies taking atypical antipsychotic medicines. CALL TOLL-FREE to study extra 1-866-961-2388 or fill out this Affected person Curiosity Kind to be contacted by our analysis coordinator. All info is saved strictly confidential. Participation consists of three cellphone interviews.

Ruta Nonacs, MD PhD

Cohen LS, Church TR, Freeman MP, Gaccione P, Caplin PS, Kobylski LA, Arakelian M, Rossa ET, Chitayat D, Hernández-Díaz S, Viguera AC.   Reproductive Security of Lurasidone and Quetiapine: Replace from the Nationwide Being pregnant Registry for Psychiatric Drugs.  J Womens Well being (Larchmt). 2023 Jan 30.

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